|Systematic (IUPAC) name|
|ATC code||P01 QP51|
|Mol. mass||398.341 g/mol|
|(what is this?)|
Melarsoprol (INN) is a medicinal drug used in the treatment of East African, (AKA rhodesiense) human African trypanosomiasis. It is also sold under the trade names “Mel B” and “Melarsen Oxide-BAL.”
Melarsoprol is also used in the treatment of trypanosomiasis, such as Chagas disease and West African sleeping sickness, the former caused by Trypanosoma cruzi and the latter by Trypanosoma brucei gambiense.
Being a toxic organic compound of arsenic, melarsoprol is a highly dangerous treatment which is only administered by injection under the supervision of a physician, as it can produce similar effects as arsenic poisoning. Among clinicians, it is colloquially referred to as "Arsenic in antifreeze".
Eflornithine is a more modern and far less dangerous treatment for sleeping sickness, but it is expensive, it is not widely available on the market, and most of its supply comes from donations from its manufacturer.
- Bisser S, N'Siesi FX, Lejon V et al. (2007). "Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei rhodesiense sleeping sickness". J. Infect. Dis. 195 (3): 322–9. doi:10.1086/510534. PMID 17205469.
- Hollingham, Richard. "Curing diseases modern medicine has left behind". New Scientist.
- Bulletin of the World Health Organization vol.84 no.10 Genebra Oct. 2006 - Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
- Chappuis F, Udayraj N, Stietenroth K, Meussen A, Bovier PA (2005). "Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis, but is not indicated for treatmenr of Trypanosoma brucei rhodesiense". Clin. Infect. Dis. 41 (5): 748–51. doi:10.1086/432576. PMID 16080099.
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