Melatonin Magik is the ninth studio album by rapper Canibus. It's his first album since his 2007 effort For Whom the Beat Tolls, and his debut on the new label War Lab Records. The album contains a consistent guest appearance by Professor Griff of Public Enemy, who provides vocals on nearly every track. The album also features other artists, such as DZK, Warbux, Blaq Poet, K-Solo, and D12 among others. On the track "Air Strike (Pop Killer)", both Canibus and DZK dis Eminem and D12, the track is considered as bait to reel Eminem into giving a response, and the track samples an interview from 2002 that Eminem had with Tim Westwood.
Artwork for Melatonin Magik features a scene inspired by movie The Matrix. Canibus sits in meditation position breaking through chains of government tyranny and lies and through the computer monitor/television screen, bringing to every potential protagonist a choice of red pill or blue pill. Similar to Redpill analogy in The Matrix listeners that choose to research Germaine's lyrics are taking the red pill, while those that disregard information Germaine presents in his lyrics choose a blue pill. It also depicts Canibus with his third eye open. Canibus commissioned this artwork after finding a Northamptonshire based graphic design artist on Spitboss.