Melorheostosis
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| Melorheostosis | |
|---|---|
| Classification and external resources | |
| ICD-10 | M85.8 |
| ICD-9 | 733.99 |
| OMIM | 155950 |
| DiseasesDB | 29229 |
| MeSH | D008557 |
Melorheostosis is a medical condition where the cortex of the bone becomes wider. Melorheostosis can be readily diagnosed on X-Rays, with its characteristic "dripping candle wax" appearance and hyper-pigmentation appearing on the bone. It is thought to be caused by a mutation of the LEMD3 gene. It tends to be monostoic (affecting only one limb), but cases affecting multiple limbs, ribs, and bones in the spine have also been reported. There are no reported cases of bones in the head or face being affected. Melorheostosis can cause severe pain, physical deformity, skin and circulation problems, contractures, and functional limitation. In severe cases amputation is considered necessary. Melorheostosis is a progressive disorder, with the severity of symptoms often depending on the age of onset.
It is associated with osteosclerosis.
Amputation of the affected limb may be necessary.[2]
[edit] References
- ^ Subhas N, Sundaram M, Bauer TW, Seitz WH, Recht MP (2008). "Glenoid labrum ossification and mechanical restriction of joint motion: extraosseous manifestations of melorheostosis". Skeletal Radiol. 37 (2): 177–81. doi:. PMID 18030463.
- ^ Graham LE, Parke RC (2005). "Melorheostosis--an unusual cause of amputation". Prosthet Orthot Int 29 (1): 83–6. doi:. PMID 16180380.
[edit] External links
The Melorheostosis Association
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