Membrane-bound transcription factor peptidase, site 1

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membrane-bound transcription factor peptidase, site 1
Symbol MBTPS1
Alt. symbols S1P SKI-1
Entrez 8720
HUGO 15456
OMIM 603355
RefSeq NM_003791
UniProt Q14703
Other data
EC number
Locus Chr. 16 q24

Membrane-bound transcription factor peptidase, site 1 also known as Site-1 Protease (S1P) or Subtilisin kexin isozyme-1 (SKI-1) is an enzyme (EC encoded by the MBTPS1 gene which cleaves the endoplasmic reticulum loop of sterol regulatory element binding protein (SREBP) transcription factors.[1][2]

See also[edit]


  1. ^ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMC 34238. PMID 10500120. 
  2. ^ Nakajima T, Iwaki K, Kodama T, Inazawa J, Emi M (2000). "Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene". J. Hum. Genet. 45 (4): 212–7. doi:10.1007/s100380070029. PMID 10944850. 

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