Membrane-bound transcription factor peptidase, site 2

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membrane-bound transcription factor peptidase, site 2
Symbol MBTPS2
Alt. symbols S2P
Entrez 51360
HUGO 15455
OMIM 300294
RefSeq NM_015884
UniProt O43462
Other data
Locus Chr. X p22.1-p22.2

Membrane-bound transcription factor peptidase, site 2 also known as Site-2 Protease (S2P) is an enzyme (EC encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element binding protein (SREBP) transcription factors from membranes.[1][2] S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases.

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  1. ^ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMC 34238. PMID 10500120. 
  2. ^ Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL (1997). "Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs". Mol. Cell 1 (1): 47–57. doi:10.1016/S1097-2765(00)80006-4. PMID 9659902. 

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