'Memory Prime' is the name of a planet home to artificial intelligences called 'Pathfinders'. These beings help Federation personnel sort the information coming from all over Federation territory. The planet is also the host to a current series of scientific award ceremonies. Unfortunately the visitors are being stalked by a killer and Spock is being accused of being part of a Vulcan terrorist cell, the Adepts of T'Pel.
The book was written by Judith and Garfield Reeves-Stevens, a married writing couple who had worked together on a series of science and technology textbooks in Canada prior to Memory Prime. They had decided that they no longer wanted to write textbooks, and after watching Star Trek IV: The Voyage Home in a cinema in New York. Afterwards they wondered if there were Star Trek novels, and they got in touch with Pocket Books. The duo submitted a series of story ideas, and the publishers selected Memory Prime. The entire correspondence between the authors and the publishers was conducted by post, with no in-person meetings. It was their first work in the Star Trek universe, and they would go on to write behind-the-scenes book, a collaboration with William Shatner and eventually write episodes for Star Trek: Enterprise.
Mary P. Taylor, in her book Star Trek: Adventures in Time and Space, described Memory Prime as "an exciting mystery and satisfyingly complex story with a lot of action and strong character development."