The Memphis & Arkansas Bridge also carries U.S. Highways 61, 64, 70 and 79 from Memphis to West Memphis; it also carried U.S. Highway 63 prior to its truncation (and later rerouting) in Arkansas. The western terminus of Tennessee State Route 1 sits on the Tennessee-Arkansas boundary halfway across the bridge.
Having been built before the introduction of the Interstate Highway System, the span was not built to Interstate Highway standards, lacking the concrete barrier between the different directions of traffic which was added later. It was also built with a sidewalk on either side of the roadway, positioned just outside the steel truss girders. The sidewalks, now also separated from the traffic lanes by concrete barriers, are accessible from Memphis city sidewalks on the Tennessee side, but give way to grassy slopes on the shoulders of I-55 on the Arkansas side.
The sidewalk and bridge is listed as part of the Mississippi River Trail. However, travel is not recommended across the sidewalk and is prohibited on the vehicle traffic lanes of the bridge, being an Interstate highway crossing. On August 12, 2012, a cyclist was killed after being struck by a vehicle when using the shoulder approaching the bridge. Within the next few years, a pedestrian/bicycle path on the neighboring Harahan Bridge will make crossing the river safer and will eliminate the need to use the I-55 bridge.