Menabitan ( INN; SP-204), or menabitan hydrochloride ( USAN), is a synthetic drug which acts as a potent cannabinoid receptor agonist. [1 ] It is closely related to [2 ] natural cannabinoids of the tetrahydrocannabinol (THC) group, differing mainly by its longer and branched side chain, and the replacement of the 9-position carbon with a nitrogen. It was studied as an [1 ] analgesic in the 1970s and was found to possess antinociceptive effects in both humans and animals but was never marketed. [1 ] [3 ] [4 ]
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References [ edit ]
^ a b c Green K, Kim K (February 1977). "Acute dose response of intraocular pressure to topical and oral cannabinoids". Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 154 (2): 228–31. PMID 402656.
^ David J. Triggle (1996). . Boca Raton: Chapman & Hall/CRC. p. 1271. Dictionary of Pharmacological Agents ISBN 978-0-412-46630-4.
^ Reggio PH (1987). "Molecular determinants for cannabinoid activity: refinement of a molecular reactivity template". NIDA Research Monograph 79: 82–95. PMID 2830539.
^ Gabriel G. Nahas (5 April 1999). . Humana Press. p. 46. Marihuana and Medicine ISBN 978-0-89603-593-5 . Retrieved 9 May 2012.
Note: The above list contains only
some known CB 1R agonists, as too many exist to list here completely. Refer here instead for more.
2-AGE (noladin ether)