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Menotropin (also called human menopausal gonadotropin or HMG) is an active substance for the treatment of fertility disturbances. It consists of gonadotropins that are extracted from the urine of postmenopausal women, usually luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Often, it contains human chorionic gonadotropin (hCG) as well.
Menotropin preparations (Ferring's Menopur and Repronex) are used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile.
Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to irrefutably demonstrate infectivity following intracerebral inoculation with urine from TSE-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.
The Practice Committee of the American Society for Reproductive Medicine reported: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”
- Van De Weijer, B. H.; Mulders, J. W.; Bos, E. S.; Verhaert, P. D.; Van Den Hooven, H. W. (2003). "Compositional analyses of a human menopausal gonadotrophin preparation extracted from urine (menotropin). Identification of some of its major impurities". Reproductive biomedicine online 7 (5): 547–557. doi:10.1016/S1472-6483(10)62071-8. PMID 14680547.
- Menotropins at the US National Library of Medicine Medical Subject Headings (MeSH)
- TheFreeDictionary > Menotropin Citing: Dorland's Medical Dictionary for Health Consumers. 2007
- fertility.com - Human Menopausal Gonadotropin (hMG) Retrieved on August 31, 2009
- Reichl H, Balen A, Jansen CA (October 2002). "Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins?". Hum. Reprod. 17 (10): 2501–8. doi:10.1093/humrep/17.10.2501. PMID 12351519.
- "Gonadotropin preparations: past, present, and future perspectives". Fertil. Steril. 90 (5 Suppl): S13–20. November 2008. doi:10.1016/j.fertnstert.2008.08.031. PMID 19007609.
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