Meptazinol

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Meptazinol
Meptazinol racemate2DCSD.svg
Systematic (IUPAC) name
(RS)-3-(3-ethyl-1-methylazepan-3-yl)phenol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Low
Routes Oral, IM, IV
Pharmacokinetic data
Metabolism The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours.
Half-life Half-Life (1.4–4 hours).
Excretion The drug is rapidly metabolised to the glucuronide, and mostly excreted in the urine.
Identifiers
CAS number 54340-58-8 N
ATC code N02AX05
PubChem CID 41049
ChemSpider 37469 YesY
UNII 18Y7S5JKZD YesY
KEGG D08182 YesY
ChEMBL CHEMBL314437 YesY
Chemical data
Formula C15H23NO 
Mol. mass 233.34922 g/mol
 N (what is this?)  (verify)

Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s.[1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[2]

It does not appear in the US Controlled Substances Act 1970; it may or may not be regulated as an analogue of controlled relatives such as proheptazine (ACSCN 9643)

References[edit]

  1. ^ US patent 4197239, Cavalla JF, Shepherd RG, White AC, "Hexahydroazepine, Piperidine and Pyrrolidine Derivatives", issued 1980-04-08, assigned to Wyeth 
  2. ^ Holmes B, Ward A (1985). "Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy". Drugs 30 (4): 285–312. doi:10.2165/00003495-198530040-00001. PMID 2998723. 

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