Mequinol

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Mequinol
4-Methoxyphenol.png
Systematic (IUPAC) name
4-Methoxyphenol
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682437
Legal status
  • CA: Unscheduled
  • US: Rx-only, Unscheduled
  • Unscheduled
Routes Topical
Identifiers
CAS number 150-76-5 YesY
ATC code D11AX06
PubChem CID 9015
ChemSpider 8665 YesY
UNII 6HT8U7K3AM YesY
KEGG D04926 YesY
ChEMBL CHEMBL544 YesY
Synonyms 4-Hydroxyanisole; para-Guaiacol
Chemical data
Formula C7H8O2 
Mol. mass 124.13722 g/mol
 YesY (what is this?)  (verify)

Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots.[1] Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation.

Chemistry[edit]

It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.

It is often used to inhibit polymerization in monomers that polymerize with radical mechanisms, such as acrylates, methacrylates or styrene.

Uses[edit]

A combination of mequinol 2% (depigmentation agent) & tretinoin 0.01% (topical retinoid) is commonly used in treating solar lentigines (liver spots & age spots). Exactly how it works is unknown, but this compound is used along with a total skin care and sunlight avoidance program. This compound may also be used for other conditions as determined by one's dermatologist. Methoxyphenol is a depigmentation agent, like Monobenzone (benzyloxyphenol), it is the active ingredient in some depigmenting creams and ointments. A formulation of 20% 4-methoxyphenol ointment causes depigmentation in animal tissue.[2]

Lower dosages of topical mequinol and the Q-switched Ruby Laser[3] have been used to depigment normal skin in vitiligo patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.

References[edit]

  1. ^ "Mequinol and Tretinoin (Topical) - MayoClinic.com". Archived from the original on 2007-08-08. Retrieved 2007-08-24. 
  2. ^ "OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR 4-METHOXYPHENOL". Retrieved 2005-10-04. 
  3. ^ "Spectrum RD 1200 Q-switched Ruby Laser". Retrieved 2006-07-26.