Mequinol, or 4-Methoxyphenol, is a phenol used in dermatology and [1 ] organic chemistry. [2 ]
Dermatology [ edit ]
Mequinol is a common
active ingredient in topical drugs used for skin depigmentation. As a topical drug Mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% Mequinol and 0.01% tretinoin by mass. [1 ] Dermatologists commonly prescribe the drug to treat solar lentigines, liver spots, or age spots.
Lower dosages of mequinol have been used in conjunction with a
Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo. [3 ]
Organic chemistry [ edit ]
In organic chemistry 4-Methoxyphenol is used to inhibit the
radical polymerization of monomers (e.g. acrylates or styrene monomers). [2 ]
Preparation [ edit ]
4-Methoxyphenol is produced from
p-benzoquinone and methanol via a free radical reaction. [4 ] [5 ]
See also [ edit ]
References [ edit ]
^ a b Stiefel Laboratories, Inc. "Full Prescribing Information" (PDF). US Food and Drug Admistration . Retrieved . 2 January 2015
^ a b Hudnall, Phillip M. (2000). "Hydroquinone". Ullmann's Encyclopedia of Industrial Chemistry. doi: 10.1002/14356007.a13_499.
^ Komen, L.; Zwertbroek, L.; Burger, S.J.; van der Veen, J.P.W.; de Rie, M.A.; Wolkerstorfer, A. (2013). "Q-switched laser depigmentation in vitiligo, most effective in active disease". British Journal of Dermatology 169 (6): 1246–1251. doi: 10.1111/bjd.12571.
^ Cristian, Gambarotti; Lucio, Melone; Carlo, Punta; Suresh Udhavrao, Shisodia (2013). "Selective Monoetherification of 1,4-Hydroquinone Promoted by NaNO. 2" Current Organic Chemistry 17 (10): 1108–1113.
^ Correale, Mariano; Panseri, Pietro; Romano, Ugo; Minisci, Francesco. "Process for the preparation of mono-ethers of hydroquinones US4933504A". Google Patents. Enichem Synthesis S.P.A . Retrieved . 2 January 2015