Mequitazine

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Mequitazine
Mequitazine.svg
Systematic (IUPAC) name
10-(4-azabicyclo[2.2.2] oct-7-ylmethyl) phenothiazine
Clinical data
Trade names Primalan
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 29216-28-2 YesY
ATC code R06AD07
PubChem CID 4066
DrugBank DB01071
ChemSpider 3926 N
UNII Y463242LY2 N
KEGG D01324 YesY
Chemical data
Formula C20H22N2S 
Mol. mass 322.468 g/mol
 N (what is this?)  (verify)

Mequitazine (trade name Primalan) is an antihistamine and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

Contraindications[edit]

Severe liver disease; premature infants or full-term neonates .

Special precautions[edit]

Pregnancy, lactation; severe CardioVascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.

Adverse drug reactions[edit]

CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.

Drug Interactions[edit]

Enhanced effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation reported with spiramycin.

See also[edit]

References[edit]

  • Ramírez Chanona N, del Rio Navarro B, Pérez Martín J (2005). "Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience". Rev Alerg Mex 52 (6): 221–5. PMID 16568706. 
  • Theunissen E, Vermeeren A, van Oers A, van Maris I, Ramaekers J (2004). "A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo.". Clin Exp Allergy 34 (2): 250–8. doi:10.1111/j.1365-2222.2004.01874.x. PMID 14987305. 
  • Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T (1998). "Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.". J Pharmacol Exp Ther 284 (2): 437–42. PMID 9454781. 
  • Persi L, Dupin O, Arnaud B, Trinquand C, Michel F, Bousquet J (1997). "Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.". Allergy 52 (4): 451–4. doi:10.1111/j.1398-9995.1997.tb01028.x. PMID 9188930.