The Mercury Lounge is a club/music venue in the Lower East Side section of New York City. The structure, at 217 East Houston Street, housed the servants to the Astor mansion, connected to it by an underground labyrinth of tunnels. Garfein's Restaurant occupied the space in the early part of the 20th century, and from 1933 to 1993 the storefront housed a seller of tombstones.
In 1993 it was converted into a music venue. It has a capacity of 250 people.
In 2000, the New York City band The Strokes got their start after playing the Mercury Lounge. Ryan Gentles, the Mercury Lounge's booker, quit his job to become the band's manager.