Meridian Southern Railway (reporting mark MDS), in east Mississippi, USA, is a 55 miles (89 km) short line freight railroad linking Meridian, and Waynesboro, Mississippi and intermediate stations. The railroad is connected to the national rail network by its connection to the Kansas City Southern Railway at Meridian. The MDS utilizes five General Electric built B23-7 locomotives to move over 7,000 carloads of freight annually.
Originally, this line was part of the Mobile and Ohio Railroad mainline connecting Mobile, Alabama with St. Louis, Missouri. The segment between Waynesboro and Mobile has been abandoned.
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