Meshchera is a plain of roughly triangular shape bounded by rivers Oka from the South, Moskva River from the Southwest, Klyazma from the North and Sudogda and Kolp/Kolpna (Колпь, Колпна) from the East. Elevation: 80–130 metres.
Climate of Meshchera is humid continental with long, cold and snowy winters, and short, warm and rainy summers. Annual average temperature is +4.3 °C (39.7 °F). The coldest month is February with average temperature of −11.6 °C (11.1 °F). During severe winters, temperatures can go as low as −47 °C (−53 °F). Summers are warm, sometimes hot, with average July temperature of +19.8 °C (67.6 °F), and in extremely hot summers temperature can rise up to +40 °C (104 °F).
It is covered by mixed forests, pine forests in sandy areas, with many wetlands and lakes.