Mesita is an unincorporated community in Costilla County, Colorado, United States. The U.S. Post Office at San Luis (ZIP Code 81152) now serves Mesita postal addresses.
Mesita is reportedly the site of some of the San Luis Valley cow mutilations. Two cows and one horse were found east of Mesita with unexplainable mutilations, including a rectal coring, and signs of being dropped from a great height.
Mesita is located at 37°05′52″N 105°36′08″W / 37.09778°N 105.60222°W / 37.09778; -105.60222 (37.097908,-105.602131).