The yeshiva has two campuses. The older campus at 145 East Broadway offers a full range of classes, from pre kindergarten through post high school. The dean, Rabbi Dovid Feinstein, is Rabbi Moshe Feinstein's eldest son. This campus has no dormitory. The second campus, also known as the Yeshiva of Staten Island is led by Rabbi Reuven Feinstein, and contains high school and post high school facilities. It contains a dormitory, located at 1870 Drumgoole Road East, in Staten Island, NY.
Founded in 1907 at 87 Eldridge Street, the Talmud Torah Tifereth Jerusalem grew quickly. First moving to 115 Hester Street, then 240 Madison, then 13 Montgomery Street, the yeshiva finally settled in two adjacent lots on 145 and 147 East Broadway. The current structure was built in 1912. A high school was established in 1929.