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IUPAC name
104206-82-8 YesY
ChEBI CHEBI:38321 YesY
ChemSpider 153301 YesY
Jmol-3D images Image
PubChem 175967
Molar mass 339.32 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Mesotrione is an herbicide sold under the brand names Callisto and Tenacity that was brought to market by Syngenta in 2001.[1] It is a synthetic analog of leptospermone developed to mimic the effects of this natural herbicide.[2] Mesotrione is a member of the class of HPPD inhibitors, which all work by inhibiting the plant enzyme 4-hydroxyphenylpyruvate dioxygenase.[3] In plants, HPPD is necessary for carotenoid biosynthesis; carotenoids in turn protect chlorophyll from being degraded by sunlight.[4] When an HPPD inhibitor is sprayed on a plant, it prevents carotenoid from being made, chlorophyll degrades and the plant dies.

Sales by Syngenta were more than $400 million per year in 2011 but worldwide patent rights started to expire in 2012, opening the market to generic competition.[1]


  1. ^ a b Dr. Nigel Uttley for Farm Chemicals International. June 3, 2011 Product Profile: Mesotrione
  2. ^ Derek Cornes (2005). "Callisto: a very successful maize herbicide inspired by allelochemistry". Fourth World Congress on Alleopathy. The Regional Institute Ltd. Retrieved May 26, 2011. 
  3. ^ Moran GR. 4-Hydroxyphenylpyruvate dioxygenase Arch Biochem Biophys. 2005 Jan 1;433(1):117-28. PMID 15581571
  4. ^ "Tenacity Herbicide". Syngenta. 

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