Metal Ions in Life Sciences

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Metal Ions in Life Sciences is a series of books edited by Astrid, Helmut and Roland Sigel, which reflects the interdisciplinary nature of biological inorganic chemistry. The series was initially published by Wiley VCH, then the Royal Society of Chemistry[1] It is now published by Springer and available to read on-line.[2] Each volume contains between 12 and 18 articles by internationally recognized experts. The series follows on from the 44-volume series entitled "Metal Ions in Biological Systems".

Historical development[edit]

The journal Bioinorganic Chemistry was founded in 1970 to publish papers in the newly emerging discipline of studies of bioinorganic chemistry. This was concerned mostly, but not entirely, with the role of metal ions. "Metal Ions in Biological Systems" was begun three years later by Helmut Sigel and subsequently his wife Astrid, both at the University of Basel. The series was published by Marcel Dekker. Over a period of somewhat more than 30 years 44 volumes were published. Their son Roland Sigel, at the University of Zurich, was also involved in the last two volumes. In 2004 Dekker has been taken over by Taylor and Francis.[3]

The Sigels then launched a new series entitled "Metal Ions in Life Sciences". The first four volumes were published by John Wiley & Sons.[4] From 2009 the series is published by the Royal Society of Chemistry.

Metal Ions in Biological Systems[edit]

From volume 9 the series ISSN number is 0161-5149

  1. Simple complexes ISBN 0-8247-6028-X
  2. Mixed-ligand complexes ISBN 0-8247-6029-8
  3. High molecular complexes ISBN 0-8247-6030-1
  4. Metal ions as probes ISBN 0-8247-6031-X
  5. Reactivity of coordination compounds ISBN 0-8247-6032-8
  6. Biological action of metal ions ISBN 0-8247-6403-X
  7. Iron in model and natural compounds ISBN 0-8247-6708-X
  8. Nucleotides and derivatives:their ligating ambivalency ISBN 0-8247-6843-4
  9. Amino acids and derivatives as ambivalent ligands ISBN 978-0-8247-6875-1
  10. Carcinogenicity and metal ions ISBN 0-8247-6843-4
  11. Metal complexes as antcancer agents ISBN 0-8247-1004-5
  12. Properties of copper ISBN 0-8247-1429-6
  13. Copper proteins ISBN 0-8247-1504-7
  14. Inorganic drugs in deficiency and disease ISBN 978-0-8247-1569-4
  15. Zinc and its role in biology and nutrition ISBN 978-0-8247-7462-2
  16. Methods involving metal ions and complexes in clinical chemistry ISBN 978-0-8247-7038-9
  17. Calcium and its role in biology ISBN 978-0-8247-7172-0
  18. Circulation of metals in the environment ISBN 978-0-8247-7551-3
  19. Antibiotics and their complexes ISBN 978-0-8247-7425-7
  20. Concepts in metal ion toxicity ISBN 978-0-8247-7540-7
  21. Application of nuclear magnetic resonance to paramagnetic species ISBN 978-0-8247-7592-6
  22. ENDOR, EPR and Electron spin echo for probing coordination spheres ISBN 978-0-8247-7641-1
  23. Nickel and its role in biology ISBN 978-0-8247-7713-5
  24. Aluminium and its role in biology ISBN 978-0-8247-7932-0
  25. Interrelations among metal ions, enzymes and gene expression ISBN 0-8247-8060-4
  26. Compendium on magnesium and its role in biology, nutrition and physiology ISBN 978-0-8247-8315-0
  27. Electron transfer reactions in metalloproteins ISBN 978-0-8247-8494-2
  28. Degradation of environmental pollutants by microorganisms and their metalloenzymes ISBN 978-0-8247-8639-7
  29. Biological properties of metal alkyl derivatives ISBN 978-0-8247-9022-6
  30. Metalloenzymes involving amino acid-residue and related radicals ISBN 978-0-8247-9093-6
  31. Vanadium and its role in life ISBN 0-8247-9383-8
  32. Interactions of metal ions with nucleotides, nucleic acids, and their constituents ISBN 978-0-8247-9549-8
  33. Probing nucleic acids by metal ion complexes of small molecules ISBN 978-0-8247-9688-4
  34. Mercury and its effects on environment and biology ISBN 0-8247-9828-7
  35. Iron transport and storage in microorganisms, plants and animals ISBN 0-8247-9984-4
  36. Interrelations between free radicals and metal ions in life processes ISBN 978-0-8247-1956-2
  37. Manganese and its role in biological processes ISBN 978-0-8247-0288-5
  38. Probing of proteins by metal ions and their low-molecular-weight complexes ISBN 978-0-8247-0289-2
  39. Molybdenum and tungsten. Their roles in biological processes ISBN 978-0-8247-0765-1
  40. The lanthanides and their interrelations with biosystems ISBN 978-0-8247-4245-4
  41. Metal ions and their complexes in medication ISBN 978-0-8247-5351-1
  42. Metal complexes in tumour diagnosis and as anticancer agents ISBN 978-0-8247-5494-5
  43. Biogeochemical cycles of elements ISBN 978-0-8493-3807-6
  44. Biogeochemistry, availability and transport of metals in the environment ISBN 978-0-8493-3820-5

Metal Ions in Life Sciences (MILS), Volumes 1-7[edit]

  1. Neurodegenerative diseases and metal ions ISBN 978-0-470-01488-2. [5]
  2. Nickel and its surprising impact in nature ISBN 978-0-470-01671-8. [6]
  1. The ubiquitous roles of cytochrome P450 proteins ISBN 978-0-470-01672-5. [7]
  2. Biomineralization. From nature to application ISBN 978-0-470-03525-2. [8]
  3. Metallothioneins and related chelators ISBN 978-1-84755-899-2. DOI 10.1039/9781847559531 Reviews[9][10][11]
  4. Metal-carbon bonds in enzymes and cofactors ISBN 978-1-84755-915-9. DOI 10.1039/9781847559333 Reviews[12][13]
  5. Organometallics in environment and toxicology ISBN 978-1-84755-177-1. DOI 10.1039/9781849730822 Review[14]

Metal Ions in Toxicology: Effects, Interactions, Interdependencies (MILS 8)[edit]

Sigel, Astrid; Sigel, Helmut; Sigel, Roland, K.O., ed. (2011). Metal Ions in Toxicology: Effects, Interactions, Interdependencies. RSC Publishing. ISBN 978-1-84973-091-4.  ISSN 1559-0836

Chapters cited in articles

Structural and Catalytic Roles of Metal Ions in RNA (MILS 9)[edit]

Sigel, Astrid; Sigel, Helmut; Sigel, Roland, K.O., ed. (2011). Structural and Catalytic Roles of Metal Ions in RNA. RSC Publishing. ISBN 978-1-84973-094-5.  ISSN 1559-0836

Chapters cited in articles

Interplay between Metal ions and Nucleic acids (MILS 10)[edit]

Sigel, Astrid; Sigel, Helmut; Sigel, Roland, K.O., ed. (2012). Interplay between Metal ions and Nucleic acids. Springer. ISBN 978-94-007-2171-5.  electronic-book ISBN 978-94-007-2172-2 ISSN 1559-0836 electronic-ISSN 1868-0402

Contents and links to articles

  1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution
  2. Nucleic Acid-Metal Ion Interactions in the Solid State
  3. Metal Ion-Promoted Conformational Changes of Oligonucleotides - Oligonucleotide
  4. G-Quadruplexes and Metal Ions - G-quadruplex
  5. Metal Ion-Mediated DNA-Protein Interactions
  6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids - Nucleic acid tertiary structure
  7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes - Oxidative stress
  8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors
  9. Enantioselective catalysis at the DNA Scaffold - Deoxyribozyme
  10. Alternative DNA Base-Pairing through Metal Coordination - Base pair
  11. Metal-Mediated Base Pairs in Nucleic Acids with Purine and Pyrimidine-Derived Neucleosides - Base pair
  12. Metal Complex Derivatives of Peptide Nucleic Acids (PNA) - Peptide nucleic acid

Cadmium:From Toxicity to Essentiality (MILS 11)[edit]

Sigel, Astrid; Sigel, Helmut; Sigel, Roland, K.O., ed. (2013). Cadmium:From Toxicity to Essentiality. Springer. ISBN 978-94-007-5178-1.  electronic-book ISBN 978-94-007-5179-8 ISSN 1559-0836 electronic-ISSN 1868-0402

Contents and links to articles

  1. The bioinorganic chemistry of cadmium in the context of its toxicity - Cadmium poisoning
  2. Biogeochemistry of cadmium and its release to the environment - Biogeochemistry, Cadmium
  3. Speciation of cadmium in the environment - Cadmium
  4. Determination of Cadmium in Biological Samples - Inductively coupled plasma mass spectrometry, cadmium
  5. Imaging and sensing of cadmium in cells - Fluorophore
  6. Use of 113Cd NMR to probe the native metal binding sites in metalloproteins: an overview - Nuclear magnetic resonance#isotopes
  7. Solid state structures of cadmium complexes with relevance to biological systems - cadmium
  8. Complex formation of cadmium with sugar residues, nucleobases, phosphates, nucleotides and nucleic acids - Stability constants of complexes
  9. Cadmium(II) complexes of amino acids and peptides - Stability constants of complexes
  10. Natural and artificial proteins containing cadmium - Metalloproteins
  11. Cadmium in metallothioneins - Metallothionein
  12. Cadmium-accumulating plants - Phytoextraction process
  13. Cadmium toxicity in plants - Toxicology
  14. Toxicology of cadmium and its damage to mammalian organs - Toxicology, Metalloestrogen
  15. Cadmium and cancer - Occupational carcinogens, cadmium
  16. Cadmium in marine phytoplankton - phytoplankton

Metallomics and the Cell (MILS 12)[edit]

Banci, Lucia, ed. (2013). Metallomics and the Cell. Series editors Sigel, Astrid; Sigel, Helmut; Sigel, Roland K.O. Springer. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 ISSN 1559-0836 electronic-ISSN 1868-0402

Contents and links to articles

  1. Metallomics and the Cell:Some Definitions and General Comments - Metallomics
  2. Technologies for Detecting Metals in Single Cells - Mass spectrometry imaging, X-ray fluorescence, Cell biology
  3. Sodium/Potassium Homeostasis in the Cell - Homeostasis, Sodium in biology, Potassium in biology
  4. Magnesium Homeostasis in Mammalian Cells - Homeostasis, Magnesium in biology, Metalloprotein
  5. Intracellular Calcium Homeostasis and Signaling - Homeostasis, Calcium in biology
  6. Manganese Homeostasis and Transport - Homeostasis, Manganese, Metalloprotein
  7. Control of Iron Metabolism in Bacteria - Iron bacteria, Human iron metabolism, Metalloprotein
  8. The Iron Metallome in Eukaryotic Organisms - Iron#Biological role, Bioinorganic chemistry#Transition metals, Metalloprotein, Iron deficiency, Iron overload
  9. Heme Uptake and Metabolism in Bacteria - Heme
  10. Cobalt and Corrinoid Transport and Biochemistry - Vitamin B12, corrinoid, cobalt#Biological role, Bioinorganic chemistry, Metalloprotein
  11. Nickel Metallomics: General Themes Guiding Nickel Homeostasis - Nickel#biological role metalloenzyme, Metalloprotein
  12. The Copper Metallome in Prokaryotic Cells - Copper#biological role, Metalloprotein
  13. The Copper Metallome in Eukaryotic Cells - Copper#biological role, metalloenzyme, Copper deficiency, Menkes disease, Wilson's disease, Copper in health#Homeostasis
  14. Zinc and the Zinc Proteome - Zinc, Metalloprotein, Nutritional neuroscience#Zinc
  15. Metabolism of Molybdenum - Molybdenum#biochemistry, Metalloprotein
  16. Comparative Genomics Analysis of the Metallomes - Genomics

Interrelations between Essential Metal Ions and Human Diseases (MILS 13)[edit]

Interrelations between Essential Metal Ions and Human Diseases. Series editors Sigel, Astrid; Sigel, Helmut; Sigel, Roland K.O. Springer. 2013. ISBN 978-94-007-7499-5.  electronic-book ISBN 978-94-007-7500-8 ISSN 1559-0836 electronic-ISSN 978-94-007-7500-8

General links: Trace metal

Contents and links to articles

  1. Metal Ions and Infectious Diseases. An Overview from the Clinic
  2. Sodium and Potassium in Health and Disease
    Sodium, Sodium in biology, Potassium, Potassium in biology
  3. Magnesium in Health and Disease
    Magnesium, Magnesium in biology, Hypermagnesemia, Hypomagnesemia
  4. Calcium in Health and Disease
    Calcium, Calcium in biology, Calcium metabolism Human homeostasis#calcium
  5. Vanadium. Its Role for Humans
    Vanadium#Biological role
  6. Chromium: Is It Essential, Pharmacologically Relevant, or Toxic?
    Chromium#Biological role
  7. Manganese in Health and Disease
    Manganese#Biological role, Manganism
  8. Iron: Effect of Overload and Deficiency
    Iron overload, Iron deficiency, Transfusion hemosiderosis, Chelation therapy, Neuropathology
  9. Cobalt: Its Role in Health and Disease
    Cobalt#Biological role, Vitamin B12, Vitamin B12 deficiency
  10. Nickel and Human Health
    Nickel#Biological role
  11. Copper: Effects of Deficiency and Overload
    Copper in health, Copper deficiency, Human homeostasis#Copper, Menkes disease, Occipital horn syndrome, Wilson's disease
  12. Zinc and Human Disease
    Zinc#Biological role, Human homeostasis#Zinc
  13. Molybdenum in Human Health and Disease
    Molybdenum#Human dietary intake and deficiency
  14. Silicon: The Health Benefi ts of a Metalloid
    Silicon#Biological role
  15. Arsenic. Can This Toxic Metalloid Sustain Life?
    Arsenic biochemistry
  16. Selenium. Role of the Essential Metalloid in Health
    Selenium in biology

The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment (MILS 14)[edit]

The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Series editors Sigel, Astrid; Sigel, Helmut; Sigel, Roland K.O. Guest Editors Peter M.H. Kroneck, Martha E. Sosa Torres. Springer. 2014. ISBN 978-94-017-9268-4.  Online ISBN 978-94-017-9269-1

Contents and links to articles

  1. The Early Earth Atmosphere and Early Life Catalysts
    Atmosphere of Earth
  2. Living on Acetylene. A Primordial Energy Source
    Acetylene#Natural occurrence, Acetylene hydratase, Metalloprotein, Tungsten#Biological role
  3. Carbon Monoxide. Toxic Gas and Fuel for Anaerobes and Aerobes: Carbon Monoxide Dehydrogenases
    Carbon monoxide dehydrogenase, metalloenzyme
  4. Investigations of the Efficient Electrocatalytic Interconversions of Carbon Dioxide and Carbon Monoxide by Nickel-Containing Carbon Monoxide Dehydrogenases
    Carbon monoxide dehydrogenase, Nickel#Biological role
  5. Understanding and Harnessing Hydrogenases, Biological Dihydrogen Catalysts
    Hydrogenase, Metalloprotein, Hydrogen cycle, Photoelectrolysis
  6. Biochemistry of Methyl-Coenzyme M Reductase: The Nickel Metalloenzyme that Catalyzes the Final Step in Synthesis and the First Step in Anaerobic Oxidation of the Greenhouse Gas Methane
    Methyl-coenzyme M reductase , Cofactor F430, Nickel#Biological role
  7. Cleaving the N,N Triple Bond: The Transformation of Dinitrogen to Ammonia by Nitrogenases
    Nitrogen fixation, nitrogenase, Molybdenum#Biological role
  8. No Laughing Matter: The Unmaking of the Greenhouse Gas Dinitrogen Monoxide by Nitrous Oxide Reductase
    Nitrous-oxide reductase, Nitrous oxide#Biological
  9. The Production of Ammonia by Multiheme Cytochromes c
    Cytochrome c, Nitrite reductase
  10. Hydrogen Sulfide: A Toxic Gas Produced by Dissimilatory Sulfate and Sulfur Reduction and Consumed by Microbial Oxidation
    Hydrogen sulfide#Participant in the sulfur cycle
  11. Transformations of Dimethylsulfide
    Dimethyl sulfide, DMSO reductase, Dimethyl-sulfide monooxygenase


  1. ^ Royal Society of Chemistry -- series website
  2. ^ Springer -- series website
  3. ^ Taylor and Francis -- series web site
  4. ^ John Wiley -- series web site
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  6. ^ . Book Reviews. J. Am. Chem. Soc. 129 (26): 8397. 2007. doi:10.1021/ja076945z. 
  7. ^ Terner, James; Gold, Avram (2007). Book Reviews. J. Am. Chem. Soc. 129 (51): 16279–16280. doi:10.1021/ja076984a. 
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  14. ^ Peter M.H. Kroneck (2011). Book Reviews. Coordination Chemistry Reviews 255 (1–2). doi:10.1016/j.ccr.2010.06.009.