Metenolone enanthate

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Metenolone enanthate
Metenolone enanthate.png
Systematic (IUPAC) name
(5α,17β)-1-Methyl-3-oxoandrost-1-en-17-yl heptanoate
Clinical data
Legal status Schedule III (US)
Pharmacokinetic data
Half-life 10.5 days
Identifiers
CAS number 303-42-4 YesY
ATC code None
PubChem CID 248271
ChemSpider 217360 YesY
Synonyms [(5S,8S,9S,10S,13S,14S,17S)-1,10,13-Trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] heptanoate
Chemical data
Formula C27H42O3 
Mol. mass 414.621 g/mol
 YesY (what is this?)  (verify)

Metenolone enanthate (methenolone enanthate) is a dihydrotestosterone (DHT) based anabolic steroid. It is an ester derivative of methenolone sold commonly under the brand names Primobolan (tablet form) or Primobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens.[medical citation needed] It is used by people who are very susceptible to estrogenic side effects, having lower estrogenic properties than nandrolone.[medical citation needed] Methenolone, in form of enanthate and acetate, is available as an injection or as an oral formulation. The injection is regarded as having a higher bioavailability. It is an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. In doses of 200 mg per week or less (intramuscular) blood pressure is rarely altered.[medical citation needed]

Methenolone can be suppressive of the hypothalamic-pituitary-gonadal axis.[1]

Use by Major League Baseball players[edit]

In February 2009, Sports Illustrated reported that Alex Rodriguez tested positive for two anabolic steroids, testosterone and metenolone enanthate, while playing for the Texas Rangers in 2003. He claims to have purchased them over the counter, in the Dominican Republic. However, "boli," as he referred to it, is an illegal substance in the Dominican Republic.[2][3] In an interview with ESPN two days after the SI revelations, Rodriguez admitted to using banned substances from 2001 to 2003, citing "an enormous amount of pressure to perform," but said he had not since then used banned performance-enhancing substances.[4][5] He said he did not know the name(s) of the particular substance(s) he was using, and would not specify whether he took them in injectable form.[4]

Methenolone enanthate, which has no approved prescriptive use in the United States of America,[2] is the same steroid to which Barry Bonds allegedly tested positive in 2000 and 2001.[3] A weak steroid on its own, it is generally used in conjunction with other steroids.[6] The drug is generally preferred in injected rather than oral form due to its cost.[6]

References[edit]

  1. ^ van Breda E, Keizer HA, Kuipers H, Wolffenbuttel BH (Apr 2003). "Androgenic anabolic steroid use and severe hypothalamic-pituitary dysfunction: a case study". Int J Sports Med 24 (3): 195–196. PMID 12740738. 
  2. ^ a b "Alex Rodriguez tested positive for steroids in 2003". Sports Illustrated. February 2009. Retrieved 2009-02-09.  By Selena Roberts and David Epstein.
  3. ^ a b Schmidt, Michael S. (2009-02-07). "Alex Rodriguez Said to Test Positive in 2003". New York Times. Retrieved 2009-02-09. 
  4. ^ a b Gammons, Peter (2009-02-09). "A-Rod admits, regrets use of PEDs". ESPN. Retrieved 2009-02-09. 
  5. ^ Schmidt, Michael S. (2009-02-09). "Rodriguez Admits to Using Performance-Enhancing Drugs". New York Times. Retrieved 2009-02-09. 
  6. ^ a b Prunty, Brendan (2009-02-07). "What is Primobolan?". Star-Ledger. Retrieved 2009-02-09.