|Systematic (IUPAC) name|
|Mol. mass||198.219 g/mol|
|(what is this?)|
Metharbital was patented in 1905 by Emil Fischer working for Merck. It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy. It has similar properties to phenobarbital.
- 1952 Gemonil was introduced by Abbott Laboratories.
- 1990 Abbott stopped marketing.
Metharbital (5,5-diethyl-1-methylbarbituric acid) is synthesized by condensation of diethylmalonic ester with methylurea.
- A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949).
- Snyder, J. A.; Link, K. P. (1953). Journal of the American Chemical Society 75 (8): 1881. doi:10.1021/ja01104a030.
- The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
- The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
- The Comparative Toxicogenomics Database: Metharbital
- US Patent 782742
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