Methdilazine

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Methdilazine
Methdilazine.svg
Systematic (IUPAC) name
10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
Clinical data
AHFS/Drugs.com monograph
Legal status
?
Identifiers
CAS number 1982-37-2 YesY
ATC code R06AD04
PubChem CID 14677
DrugBank DB00902
ChemSpider 14009 YesY
UNII 4Q13LY9Z8X YesY
KEGG D04979 YesY
ChEMBL CHEMBL1200959 N
Chemical data
Formula C18H20N2S 
Mol. mass 296.431 g/mol
 N (what is this?)  (verify)

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

Synthesis[edit]

Methdilazine synthesis:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; U.S. Patent 2,945,855 (1960).

See also[edit]

References[edit]

  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959). R. F. Feldkamp and Y. H. Wu,
  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943. 
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532. 
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung 38 (7): 869–72. PMID 2905130. 

The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.