This was the first album released after the departure of guitarist and founding member Travis Threlkel, and the only album to feature vocalists Elise Dye and Paola Simmonds. Drummers Brian Glaze and Graham Bonnar were also brought into the line-up to replace Ricky Maymi who had begun playing bass in the band. It was also Graham Bonnar's only appearance in the band. "She Made Me" and "Evergreen" were released as a double A-side single in 1992. Methodrone was re-released in 2007 on Anton Newcombe's A Records.
The second album by a band that had been steadily releasing singles throughout the two years previous, Methodrone was largely ignored upon its release. However, it garnered a favorable review in British tastemaker magazine Mojo, where Brian Bannin wrote, "Everything moves with the slowness and presence of a disgraced monarch in exile...At its best, Methodrone has the tormented grace of accepting doom".