Methoxamine

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Not to be confused with methoxetamine.
Methoxamine
Methoxamine.png
Systematic (IUPAC) name
2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
390-28-3 YesY
C01CA10
PubChem CID 6082
IUPHAR ligand 483
DrugBank DB00723 N
ChemSpider 5857 YesY
UNII HUQ1KC1YLI YesY
KEGG D08201 YesY
ChEMBL CHEMBL524 YesY
Chemical data
Formula C11H17NO3
211.258
 N (what is this?)  (verify)

Methoxamine is an α1-adrenergic receptor agonist,[1] similar in structure to phenylephrine and 2,5-DMA. It was developed by Burroughs-Wellcome in the 1940s.[2] The drug induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.

See also[edit]

References[edit]

  1. ^ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003]. "5". In Goljan, Edward F. Pharmacology (PAPERBACK). Rapid Review (Second ed.). Philadelphia, PA: Mosby-Elsevier. p. 39. ISBN 978-0-323-04550-6. 
  2. ^ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE