Methoxy arachidonyl fluorophosphonate

Methoxy arachidonyl fluorophosphonate
	IUPAC name methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenylphosphonofluoridate
	Other names MAFP
Identifiers
PubChem	10429254
ChemSpider	8604682
ChEMBL	CHEMBL113262
Jmol-3D images	Image 1
	SMILES FP(=O)(OC)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC ;
	InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16- ; Key: KWKZCGMJGHHOKJ-ZKWNWVNESA-N InChI=1/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-; Key: KWKZCGMJGHHOKJ-ZKWNWVNEBX ;
Properties
Molecular formula	C21H36FO2P
Molar mass	370.5
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

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Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases ^[1]. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC₅₀ values in the low-nanomolar range.

[edit] See also

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