Methylcholanthrene

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3-Methylcholanthrene
3-Me-cholanthrene chemical structure.svg
Methylcholanthrene.png
Identifiers
Abbreviations 3-MC
20-MC
CAS number 56-49-5 YesY
PubChem 299006
ChemSpider 264105 YesY
ChEBI CHEBI:34342 N
ChEMBL CHEMBL40583 N
Jmol-3D images Image 1
Properties
Molecular formula C21H16
Molar mass 268.35 g/mol
Appearance Yellow solid
Melting point 180 °C (356 °F; 453 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Methylcholanthrene (MCA) is a highly carcinogenic polycyclic aromatic hydrocarbon produced by burning organic compounds at very high temperatures[clarification needed]. It is a yellow solid with a melting point around 180 °C. Methylcholanthrene is used in laboratory studies of chemical carcinogenesis. It is an alkylated derivative of benz[a]anthracene and has a similar UV spectrum. The most common isomer is 3-methylcholanthrene, although the methyl group can occur in other places.

3-Methylcholanthrene, a known carcinogen which builds up in the prostate due to cholesterol breakdown, is implicated in prostate cancer.[citation needed] It "readily produces" primary sarcomas in mice.[1]

References[edit]

  1. ^ Donald C. Malins, Katie M. Anderson, Naomi K. Gilman, Virginia M. Green, Edward A. Barker and Karl Erik Hellström (2004). "Development of a Cancer DNA Phenotype Prior to Tumor Formation". PNAS 101 (29): 10721–10725. doi:10.1073/pnas.0403888101. JSTOR 3372726. PMC 490001. PMID 15249662. 

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