Methyldesorphine is an opioid analgesic. First synthesized in Germany in 1940 and patented in the USA in 1952, it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics. It is approximately 15 times more potent than morphine as an analgesic but if the 6-7 bond is saturated, the β isomer is some 50 times more potent than morphine.
^US patent 2694068, Payne, G. B. et al., "Δ6-DESOXYMORPHINE COMPOUNDS AND PROCESS OF PRODUCING THE SAME", published 1952-08-05, issued 1954-09-11
^Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2008). "Chromatographic Study of Expert and Biological Samples Containing Desomorphine". Journal of Analytical Chemistry63 (4): 361–370. doi:10.1007/s10809-008-4009-5.edit
^Casy, A. F.; Parfitt, R. Y. (1986). Opioid Analgesics, Chemistry and Receptors. New York: Plenum Press. pp. 37–38. ISBN0-306-42130-5.
^Lenz, G. R.; Evans, S. M.; Walters, D. E.; Hopfinger, A. J. (1986). Opiates. Academic Press. p. 63. ISBN978-0-12-443830-9.