Methyldesorphine

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Methyldesorphine
Methyldesorphine.svg
Systematic (IUPAC) name
(5α)-6,17-Dimethyl-6,7-didehydro-4,5-epoxymorphinan-3-ol
Clinical data
Legal status
Identifiers
CAS number 16008-36-9 YesY
ATC code None
PubChem CID 5362518
ChemSpider 4515065 N
UNII Y460N7W76B N
Synonyms 3-Hydroxy-6,N-dimethyl- 4,5-epoxymorphin-6-en
Chemical data
Formula C18H21NO2 
Mol. mass 283.36 g/mol
 N (what is this?)  (verify)

Methyldesorphine is an opioid analgesic. First synthesized in Germany in 1940 and patented in the USA in 1952,[1] it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics.[2] It is approximately 15 times more potent than morphine as an analgesic[3][4] but if the 6-7 bond is saturated, the β isomer is some 50 times more potent than morphine.

Methyldesorphine is listed as a Schedule I Narcotic controlled substance under the Controlled Substances Act 1970 in the United States with a DEA ACSCN of 9302 and zero annual aggregate manufacturing quota. The free base conversion ratio of the hydrochloride is 0.89.[5]

See also[edit]

References[edit]

  1. ^ US patent 2694068, Payne, G. B. et al., "Δ6-DESOXYMORPHINE COMPOUNDS AND PROCESS OF PRODUCING THE SAME", published 1952-08-05, issued 1954-09-11 
  2. ^ Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2008). "Chromatographic Study of Expert and Biological Samples Containing Desomorphine". Journal of Analytical Chemistry 63 (4): 361–370. doi:10.1007/s10809-008-4009-5.  edit
  3. ^ Casy, A. F.; Parfitt, R. Y. (1986). Opioid Analgesics, Chemistry and Receptors. New York: Plenum Press. pp. 37–38. ISBN 0-306-42130-5. 
  4. ^ Lenz, G. R.; Evans, S. M.; Walters, D. E.; Hopfinger, A. J. (1986). Opiates. Academic Press. p. 63. ISBN 978-0-12-443830-9. 
  5. ^ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html