Methylmalonyl-CoA

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Methylmalonyl-CoA
Methylmalonyl-CoA.PNG
Names
IUPAC name
(9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]-3,5,9-trihydroxy-8,8,20-trimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicosan-21-oic acid 3,5-dioxide (non-preferred name)
Identifiers
1264-45-5 YesY
ChEBI CHEBI:16625 N
ChemSpider 110440 N
Jmol-3D images Image
PubChem 123909
Properties
C25H40N7O19P3S
Molar mass 867.608 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Methylmalonyl-CoA is the thioester consisting of coenzyme A linked to methylmalonic acid. It is an important intermediate in the biosynthesis of many organic compounds as well as in the process of carbon assimilation.[1]

Biosynthesis and conversions[edit]

Methylmalonyl-CoA is formed from propionyl-CoA by propionyl-CoA carboxylase by help of biotin (vitamin B7). It is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle. The following diagram demonstrates the aforementioned reactions:[2]

Propionyl CoA → Methylmalonyl CoA → Succinyl CoA

See also[edit]

References[edit]

  1. ^ Tabita, F. R., "The hydroxypropionate pathway of CO2 fixation: Fait accompli", Proceedings of the National Academy of Sciences 2009, vol. 106, 21015-21016. doi:10.1073/pnas.0912486107
  2. ^ Nelson, David L.; Cox, Michael M. (2005), Principles of Biochemistry (4th ed.), New York: W. H. Freeman, ISBN 0-7167-4339-6