Methylmalonyl-CoA
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| Methylmalonyl-CoA | |
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| Identifiers | |
| CAS number | 1264-45-5 |
| PubChem | 123909 |
| MeSH | methylmalonyl-coenzyme+A |
| Properties | |
| Molecular formula | C25H40N7O19P3S |
| Molar mass | 867.608 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Methylmalonyl-CoA is the thioester consisting of coenzyme A linked to methylmalonic acid. It is an important intermediate in the biosynthesis of many organic compounds as well as in the process of carbon assimilation.[1]
Biosynthesis and conversions [edit]
Methylmalonyl-CoA is formed from propionyl-CoA by propionyl-CoA carboxylase by help of biotin (vitamin B7). It is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle. The following diagram demonstrates the aforementioned reactions:[2]
- Propionyl CoA → Methylmalonyl CoA → Succinyl CoA
See also [edit]
References [edit]
- ^ Tabita, F. R., "The hydroxypropionate pathway of CO2 fixation: Fait accompli", Proceedings of the National Academy of Sciences 2009, vol. 106, 21015-21016. doi:10.1073/pnas.0912486107
- ^ Nelson, David L.; Cox, Michael M. (2005), Principles of Biochemistry (4th ed.), New York: W. H. Freeman, ISBN 0-7167-4339-6
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