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Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status ?
CAS number 56-04-2
ATC code H03BA01
PubChem CID 667493
ChemSpider 580871
UNII QW24888U5F YesY
KEGG C19265 YesY
Chemical data
Formula C5H6N2OS 
Mol. mass 142.18 g/mol
 YesY (what is this?)  (verify)

Methylthiouracil is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

Methylthiouracil is not used clinically in the United States, it has a similar mechanism of action and side effect to that of propylthiouricil.

The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.

The clinical effects of the drug to treat the hyperthyroid state can have a lag period of up to two weeks, depending on the stores of thyroglobulin and other factors.

Side effects[edit]

Like with any drug a wide variety of side effects can occur, but four topics should be kept in mind and the patient informed:

Agranulocytosis - develops rapidly, sore throat and fever are hallmark symptoms. Can be fatal if drug is not discontinued promptly.

Allergic skin reactions the most dangerous of which is Exfoliative Dermatitis, it rapidly can get out of control, notify the physician should a skin eruption occur.

Hepatitis - yellowing of the skin, nausea, yellowing of the whites of the eyes, flu-like symptoms.

Thrombocytopenia - unusual bruising or bleeding.

External links[edit]

see link on discussion of Hyperthyrodism: