The station logo depicts an old steam locomotive. Near the site of the metro station stood the San Lázaro mainline train station. San Lázaro was the main terminus for the Interoceanic Railway, which linked the port of Veracruz, on the Gulf of Mexico, with the Pacific Ocean. Today, some railway tracks can still be seen near the metro station, but nothing more.
San Lázaro metro station is connected with TAPO, Mexico City's Eastern intercity bus station. This bus station serves states including Puebla, Veracruz, Oaxaca, and Yucatán. It is used by some of the most prestigious and safest bus lines in Mexico, such as ADO, UNO, and Maya de Oro.