Mezlocillin

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Mezlocillin
Mezlocillin.svg
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-
2-oxo-imidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]
amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-
carboxylic acid
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.
  • B
Legal status
?
Routes Intravenous, intramuscular
Pharmacokinetic data
Protein binding 16–59%
Metabolism Hepatic (20–30%)
Half-life 1.3–4.4 hours
Excretion Renal (50%) and biliary
Identifiers
CAS number 51481-65-3 YesY
ATC code J01CA10
PubChem CID 656511
DrugBank DB00948
ChemSpider 570894 YesY
UNII OH2O403D1G YesY
KEGG D05021 YesY
ChEBI CHEBI:6919 YesY
ChEMBL CHEMBL1731 YesY
Chemical data
Formula C21H25N5O8S2 
Mol. mass 539.584 g/mol
 YesY (what is this?)  (verify)

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending colangitis.

Mechanism of action[edit]

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Susceptible organisms[edit]

Gram-negative[edit]

Gram-positive[edit]

External links[edit]