Malkova was introduced to the adult film industry by adult actress Natasha Malkova, who was a school friend of hers. She is represented by the agency Matrix Models.
She was the "Twistys Treat of the Month" in December 2012 and the 2013 "Twistys Treat of the Year". She chose the name Mia Malkova to sound more Russian, indicating in an interview that she felt it a more appealing name like that of a European supermodel. Despite this, she has also performed under several other pseudonyms.
In June 2014, the sex toy manufacturer Doc Johnson announced that it was releasing a new product based on a mold of Malkova's genitalia.