Together with Marc Cherry and Tom Spezialy, Edelstein was one of the original executive producers for Desperate Housewives, for which he was awarded an Emmy nomination and won two Golden Globes for best comedy series. Following creative conflicts with series creator Cherry during the second season of the series, Edelstein left the series in January 2006.
In addition to Desperate Housewives, Edelstein has been executive producer for the thriller series Threat Matrix, and the sitcom Hope & Faith, as well as telefilms Haunting Sarah from 2005 and Him and Us from 2006. He is also executive producer for the 2009 space drama, Defying Gravity.
Edelstein also helped launch the CSI drama franchise when he was Director, Current Programs at CBS Entertainment.  He joined NBCUniversal International in June 2010 as President of International TV Production and relocated to London  NBC Universal International’s inhouse production labels include Carnival, creators of Emmy and Golden Globe winning Downton Abbey,
 entertainment label Monkey Kingdom which produces BAFTA award-winning Made in Chelsea; http://www.broadcastnow.co.uk/news/indies/nbcu-acquires-monkey-kingdom/5020605.article; Chocolate Media a factual/entertainment label;  and Lucky Giant Productions which specialises in comedy  Outside of the UK, NBCU International has deals with LARK Productions in Canada, producers of Real Housewives of Vancouver and Matchbox Pictures In Australia, producers of The Slap   Edelstein also serves as a board member of WTTV, NBC Universal’s joint TV production venture with Working Title
- Keck, William: Wisteria Lane's new landscape, USA Today, May 19, 2006
- http://www.variety.com/article/VR1118020008 http://www.screendaily.com/news/production/michael-edelstein-takes-international-tv-post-at-nbc-universal/5014514.article