Michael Grunstein

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Michael Grunstein
Mgrunstein.jpg
Born 1946 (age 67–68)
Romania
Fields Biological Chemistry
Institutions David Geffen School of Medicine at UCLA
Alma mater McGill University
University of Edinburgh
Notable awards the Massry Prize from the Keck School of Medicine, University of Southern California in 2003

Michael Grunstein (born 1946 in Romania) is a Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA.[1][2]

The only surviving child of Holocaust survivors,[3] he obtained his Bachelor of Science degree from McGill University in Montreal, and his PhD from the University of Edinburgh, Scotland. He did his post-doctoral training at Stanford University in Palo Alto, California, where he invented the colony hybridization screening technique for recombinant DNAs in David Hogness' laboratory.[4]

Soon after coming to UCLA in 1975, Grunstein pioneered the genetic analysis of histones in yeast and showed for the first time that histones are regulators of gene activity in living cells. His studies were among the most influential to counter the prevailing belief in the 1980s that eukaryotic genes, like previously studied bacterial genes, were predominantly subjected to transcriptional activation. His laboratory's studies provided inspiration for the eukaryotic histone code and underlie the modern study of epigenetics.

He received the Massry Prize from the Keck School of Medicine, University of Southern California in 2003 (with Roger Kornberg and David Allis). In April 2008, Grunstein was elected into the National Academy of Sciences.

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References[edit]

  1. ^ Morber, J. R. (2011). "Profile of Michael Grunstein". Proceedings of the National Academy of Sciences 108 (46): 18597–18599. doi:10.1073/pnas.1116909108. PMID 22084101.  edit
  2. ^ "Michael Grunstein, Ph.D. Distinguished Professor, Biological Chemistry, David Geffen School of Medicine, UCLA". Retrieved 2011-11-17. 
  3. ^ Morber, Jenny Ruth (2011). "Profile of Michael Grunstein". Proceedings of the National Academy of Sciences 108 (46): 18597–18599. doi:10.1073/pnas.1116909108. 
  4. ^ Grunstein, M.; Hogness, D. S. (1975). "Colony hybridization: A method for the isolation of cloned DNAs that contain a specific gene". Proceedings of the National Academy of Sciences of the United States of America 72 (10): 3961–3965. doi:10.1073/pnas.72.10.3961. PMC 433117. PMID 1105573.  edit

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