Michael Keppele (September 9, 1771 – February 2, 1821) was a lawyer, alderman, and mayor of Philadelphia, 1811–1812.
Graduated from the University of the State of Pennsylvania (now the University of Pennsylvania) in 1788. He was admitted to the Philadelphia bar on September 18, 1792. In 1806, he became an alderman, replacing Michael Hillegas. He was elected mayor on October 15, 1811, and served a one-year term.
He died in Philadelphia.
He married Catherine Caldwell (June 7, 1774 – August 23, 1862).
Their daughter Sarah Caldwell Keppele (1789–1877) married James Cornell Biddle (1795–1838), of the Philadelphia Biddle family in 1825. He was son of revolutionary war soldier Clement Biddle (1740–1814).
- Penn Students in the 18th Century: Classes of 1780-1789, Univ. Pennsylvania.
- History of the Friendly Sons of St. Patrick and of the Hibernian Society for the Relief of Emigrants from Ireland: March 17, 1771-March 17, 1892, by John Hugh Campbell, published by Hibernian Society, 1892.
- "Biddle family papers". University of Delaware Library. Retrieved March 23, 2011.
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