Microsomal triglyceride transfer protein

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Microsomal triglyceride transfer protein
Identifiers
Symbols MTTP ; ABL; MTP
External IDs OMIM157147 MGI106926 HomoloGene212 ChEMBL: 2569 GeneCards: MTTP Gene
RNA expression pattern
PBB GE MTTP 205675 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4547 17777
Ensembl ENSG00000138823 ENSMUSG00000028158
UniProt P55157 O08601
RefSeq (mRNA) NM_000253 NM_001163457
RefSeq (protein) NP_000244 NP_001156929
Location (UCSC) Chr 4:
100.48 – 100.55 Mb
Chr 3:
138.09 – 138.14 Mb
PubMed search [1] [2]

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[1][2]

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[2]

Apoprotein B48 on chylomicra and Apoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

Pharmacology[edit]

Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

References[edit]

  1. ^ Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381. 
  2. ^ a b "Entrez Gene: MTTP microsomal triglyceride transfer protein". 

Further reading[edit]