Migrating motor complexes (or migrating myoelectric complex or migratory motor complex or migratory myoelectric complex or MMC) are waves of activity that sweep through the intestines in a regular cycle during a fasting state. These motor complexes help trigger peristaltic waves, which facilitate transportation of indigestible substances such as bone, fiber, and foreign bodies from the stomach, through the small intestine, past the ileocecal sphincter, and into the colon. The MMC originates in the stomach roughly every 5 to 10 minutes during the interdigestive phase (between meals) and is responsible for the rumbling experienced when hungry. The MMC lasts for approximately 1 minute.
Morphine, has been found at relatively low doses to stimulate phase III of the migrating motor complex.
Trimebutine is one drug that as part of its therapeutic action causes a premature activation of phase III of the migrating motor complex in the digestive tract.