Mike Keefe (born 6 November 1946, in Santa Rosa, California) is an American editorial cartoonist best known for his work at The Denver Post, for which he has drawn cartoons since 1975. His cartoons are nationally syndicated, and have appeared in hundreds of newspapers as well as in Europe, Asia, and most major U.S. news magazines.
Keefe is the author of three books: Running Awry, Keefe-Kebab, and The Ten-Speed Commandments. He plays guitar and harmonica for the rock & roll band Falling Rock. Keefe is also a member of the Triple Nine Society.