In 1960, Sasaki graduated from Waseda University with a bachelor's degree in industrial engineering and management. That April he went to work for Mitsubishi Corporation where he stayed ever since. From 1993 to 1994 he was president of the American subsidiary Mitsubishi International Corp. in New York City. In 1994 he became a managing director in Japan, and the next year he became overall managing director of administration. In 1998 he became president and chief executive officer, and in 2004 he became chairman of the board.
- (September 2008) "三菱商事の佐々木会長が国際商業会議所のボード入り" ("Sasaki, chairman of Mitsubishi Corporation's international board, to the Chamber of Commerce") in Japanese from the September 2008 issue of ビジネス・インサイド (Business Inside), accessed 3 October 2008
- Marquis Who’s Who (corp.) (2008) "Mikio Sasaki 1937- " Who's Who in Finance and Business - 2008-2009 (36th Edition) Marquis Who's Who, New Providence, NJ
- Schlager, Neil (ed.) (2005) "Mikio Sasaki 1937- " International Directory of Business Biographies St. James Press, Detroit
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