Hughes started his acting career in a public service announcement when he was 22 months old, and followed that up by appearing in his first feature film five months later. From his years as a child actor, Hughes was consistently one of the busiest young actors in Hollywood. He played Aaron Bailey on Full House from 1990 to 1995. One of his first films was Jack the Bear, opposite Danny DeVito; in addition, he has starred on film in Pet Sematary (1989), Kindergarten Cop (1990), Apollo 13 (1995), Spawn (1997), Zeus and Roxanne (1997), and Mercury Rising (1998) alongside Bruce Willis. Hughes has also appeared in numerous television movies. He has been a series regular, recurring character or guest star on many television series including Baywatch (1989), Sister Kate (1989–1990), Beverly Hills, 90210 (1991) Full House (1992), Melrose Place (1992), Touched by an Angel (1994) and The Nanny (1994). Hughes received an Emmy Award certificate for his participation as the voice of "Tommy" in the number one-rated Fox animated television series Life with Louie (1995). His other voiceover credits include the voice of "Sly" and "Witt", twin babies in the feature film Baby Geniuses (1999). His latest project is the film Surf School. Hughes recently appeared in a commercial for the video game "Jaks". After a break in his career he re-emerged as a teen in the science fiction hit Roswell. Hughes played a lovable villain who was part of a renegade group of aliens. As a musician, he released 2 albums in 1995, when he was just 9. One is self-titled and the other is called "Halloween Haunts". Miko wrote songs for both albums and sings as well. They were recorded and released by his own company called "Little Chief, Inc". In 2013 Hughes directed the segment See in the horror anthology film Chilling Visions: 5 Senses of Fear.