Marks released her debut single, "Freeway Bound," in 2005. It was followed by her debut album, also titled Freeway Bound, which was released on September 13, 2005. Three further singles ("Kickin' Back," "Mama," and "Don't Come Cryin' to Me") were released from the album in 2006. "Mama" featured Marks' first music video, which included a guest appearance by Erykah Badu assuming the title role. Her second studio album, It Feels Good, followed in 2007 after the release of lead-off single "Locked and Loaded." Both were produced by Ron Cornelius and released under the Mirrome Records imprint. 
In his review of It Feels Good, Stewart Mason of allmusic awarded the album 3 and 1/2 stars, drawing comparisons to the Dixie Chicks and Gretchen Wilson while commenting that the album "clicks on every level, making it a solidly enjoyable neo-traditionalist country listen."
Despite receiving critical praise for her work, Miko Marks has failed to chart any of her albums or singles on the Billboard charts.