Minaprine

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Minaprine
Minaprine.svg
Systematic (IUPAC) name
4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • Prescription only
Routes Oral
Pharmacokinetic data
Half-life 2-2.5 hours
Identifiers
CAS number 25905-77-5 YesY
ATC code N06AX07
PubChem CID 4199
ChemSpider 4054 N
UNII 00U7GX0NLM N
KEGG D05039 YesY
ChEMBL CHEMBL278819 N
Chemical data
Formula C17H22N4O 
Mol. mass 298.383 g/mol
 N (what is this?)  (verify)

Minaprine (Brantur, Cantor) is an antidepressant that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.[1]

A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.[2] In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.[3]

See also[edit]

References[edit]

  1. ^ Fung, M.; Thornton, A.; Mybeck, K.; Wu, J. H.-h.; Hornbuckle, K.; Muniz, E. (1 January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. doi:10.1177/009286150103500134. 
  2. ^ Kan JP, Mouget-Goniot C, Worms P, Biziere K (1986). "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology 35 (6): 973–978. doi:10.1016/0006-2952(86)90085-7. PMID 3954800. 
  3. ^ Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (1999). "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry 42 (4): 730–741. doi:10.1021/jm981101z. PMID 10052979.