Minaprine

Minaprine
Systematic (IUPAC) name
	4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Half-life	2-2.5 hours
Identifiers
CAS number	25905-77-5
ATC code	N06AX07
PubChem	CID 4199
ChemSpider	4054
UNII	00U7GX0NLM
KEGG	D05039
ChEMBL	CHEMBL278819
Chemical data
Formula	C17H22N4O
Mol. mass	298.383 g/mol
	SMILES CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3;
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Minaprine (Brantur, Cantor) is an antidepressant used in France for the treatment of depression.^{[citation needed]} A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.^[1] In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.^[2]

Chemitry^{[citation needed]}[edit]

^ Kan JP, Mouget-Goniot C, Worms P, Biziere K (1986). "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology 35 (6): 973–978. PMID 3954800.
^ Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (1999). "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry 42 (4): 730–741. PMID 10052979.

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