A longtime fan of comics, particularly of Marvel's Spider-Man, Mindy Newell sent submissions to DC Comics in 1983 at a time when the company was actively looking for new talent. Her first professional work was her creation of the character Jenesis, who appeared in three issues of New Talent Showcase. Editor Karen Berger called her in for an interview four days after DC received her submission, according to the creator biography in New Talent Showcase #9. Jenesis, whose real name was Alix Ward, was named after Newell's daughter, Alixandra . Hired by editors Dick Giordano and Karen Berger, Newell wrote fill-in issues for Legion of Super-Heroes and Action Comics. In 1986, she and artist Gray Morrow collaborated on a Lois Lane limited series which dealt with the subject of missing children. In addition, Newell wrote Wonder Woman, and Her Sister's Keeper, a seminal Catwoman limited series. Newell also briefly worked on First Comics's American Flagg and Eclipse Comics's The New Wave.
Newell has always maintained a career as a nurse while writing comics, and has since returned to that occupation full-time.
Her spouse John Higgins is a British comic book writer, illustrator, and letterer.
^Manning, Matthew K.; Dolan, Hannah, ed. (2010). "1980s". DC Comics Year By Year A Visual Chronicle. Dorling Kindersley. p. 239. ISBN978-0-7566-6742-9. "Written by Mindy Newell, with art by J.J. Birch, Catwoman picked up where Frank Miller's "Year One" story arc left off."