The airline was established in October 1981 to promote a system of rapid air transport for parcels and other services using small aircraft and airports. It started operations in 1982 when it was the first Italian airline to begin overnight flights. In September 1988 it started operations on behalf of FedEx, UPS and Italian Post. It has 90 employees (at March 2007).
On 31 January 2015, the Italian authorities revoked the company's air operator's certificate due to its financial situation. MiniLiner can therefore no longer operate any flights until further notice.