Mirfentanil
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| Mirfentanil | |
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N-[1-(2-phenylethyl)piperidin-4-yl]-N-pyrazin-2-yl-2-furamide |
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Other names
MS-32, NIH-10647 |
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| Identifiers | |
| CAS number | 117523-47-4 |
| PubChem | 60698 |
| Jmol-3D images | {{#if:C1CN(CCC1N(C2=NC=CN=C2)C(=O)
C3=CC=CO3)CCC4=CC=CC=C4|Image 1 |
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| Properties | |
| Molecular formula | C22H24N4O2 |
| Molar mass | 376.45 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Mirfentanil is a fentanyl derivative with strong selectivity for the μ opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone.[1]
At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.[1][2]
References [edit]
- ^ a b France CP, Winger G, Medzihradsky F, Seggel MR, Rice KC, Woods JH. "Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects." Journal of Pharmacology and Experimental Therapeutics. 1991 Aug;258(2):502-10. PMID 1650830
- ^ Carr DJ, Brockunier LL, Scott M, Bagley JR, France CP. "Mirfentanil antagonizes morphine-induced suppression of splenic NK activity in mice." Immunopharmacology. 1996 Aug;34(1):9-16. PMID 8880221
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