The film will feature Mr. Peabody, a talking dog who is the smartest being in the world, and his "pet" boy Sherman. When Sherman's use of their time traveling WABAC machine results in disastrous and comical results, it is up to them to put things on track before the space-time continuum is irreparably destroyed.
In The Simpsons, fifth Halloween Special (Treehouse of Horror V), in the Time and Punishment episode, Homer finds himself able to travel through time by means of a magic toaster and comes across Mr. Peabody and Sherman. The characters Kang and Kodos later take on Peabody's and Sherman's appearances due to Homer's meddling with the timestream.
In Time Squad, the character Otto is modeled off of Sherman.
In Family Guy, episode The Kiss Seen Around the World, Peter and Brian travel back in time to see Christopher Columbus. The two don similar looks to Sherman and Mister Peabody; the flashback also parodies the format of the show, with the two going back in time and Brian (the dog) teaching Peter (the human).
The 1985 film Back to the Future had a character named Otis Peabody and a son named Sherman, which was tribute to the animated characters. Unlike the famed duo, this Sherman and Mr. Peabody are hostile towards Marty and his time travel.