Mitchell S. Weiss (born 1957) is an American investigative journalist, and editor of the Charlotte Observer. He won the 2004 Pulitzer Prize for Investigative Reporting, with Joe Mahr and Michael D. Sallah.
Weiss is a native of New York City. He graduated from Northwestern University with an MS in journalism in 1982. He was an Associated Press reporter in Toledo and Columbus, Ohio. From 1998 to 2005 he worked for The Blade . In 2005, he was deputy business editor of The Charlotte Observer. In 2008, he was correspondent to the Charlotte Bureau of the Associated Press.