Mitogen-activated protein kinase 9

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Mitogen-activated protein kinase 9
Protein MAPK9 PDB 3E7O.png
Rendering based on PDB 3E7O.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAPK9 ; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; SAPK; SAPK1a; p54a; p54aSAPK
External IDs OMIM602896 MGI1346862 HomoloGene55685 ChEMBL: 4179 GeneCards: MAPK9 Gene
EC number 2.7.11.24
RNA expression pattern
PBB GE MAPK9 203218 at tn.png
PBB GE MAPK9 210570 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5601 26420
Ensembl ENSG00000050748 ENSMUSG00000020366
UniProt P45984 Q9WTU6
RefSeq (mRNA) NM_001135044 NM_001163671
RefSeq (protein) NP_001128516 NP_001157143
Location (UCSC) Chr 5:
179.66 – 179.72 Mb
Chr 11:
49.85 – 49.89 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.[1]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Interactions[edit]

Mitogen-activated protein kinase 9 has been shown to interact with TOB1,[3] Grb2,[4][5] MAPK8IP2,[6] P53,[7][8] MAPK8IP3[9][10] and MAPK8IP1.[6][11]

References[edit]

  1. ^ Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R, Karin M (January 1995). "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes Dev 8 (24): 2996–3007. doi:10.1101/gad.8.24.2996. PMID 8001819. 
  2. ^ "Entrez Gene: MAPK9 mitogen-activated protein kinase 9". 
  3. ^ Maekawa, Momoko; Nishida Eisuke, Tanoue Takuji (October 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". J. Biol. Chem. (United States) 277 (40): 37783–7. doi:10.1074/jbc.M204506200. ISSN 0021-9258. PMID 12151396. 
  4. ^ Saleem, A; Datta R, Yuan Z M, Kharbanda S, Kufe D (December 1995). "Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents". Cell Growth Differ. (UNITED STATES) 6 (12): 1651–8. ISSN 1044-9523. PMID 9019171. 
  5. ^ Kharbanda, S; Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum R, Woodgett J, Avruch J, Kyriakis J (August 1995). "Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase". J. Biol. Chem. (UNITED STATES) 270 (32): 18871–4. doi:10.1074/jbc.270.32.18871. ISSN 0021-9258. PMID 7642542. 
  6. ^ a b Yasuda, J; Whitmarsh A J, Cavanagh J, Sharma M, Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7245–54. ISSN 0270-7306. PMC 84717. PMID 10490659. 
  7. ^ Hu, M C; Qiu W R, Wang Y P (November 1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene (ENGLAND) 15 (19): 2277–87. doi:10.1038/sj.onc.1201401. ISSN 0950-9232. PMID 9393873. 
  8. ^ Lin, Yenshou; Khokhlatchev Andrei, Figeys Daniel, Avruch Joseph (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. (United States) 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. ISSN 0021-9258. PMID 12384512. 
  9. ^ Ito, M; Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto K I (November 1999). "JSAP1, a Novel June N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7539–48. ISSN 0270-7306. PMC 84763. PMID 10523642. 
  10. ^ Kelkar, N; Gupta S, Dickens M, Davis R J (February 2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. ISSN 0270-7306. PMC 85220. PMID 10629060. 
  11. ^ Whitmarsh, A J; Cavanagh J, Tournier C, Yasuda J, Davis R J (September 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science (UNITED STATES) 281 (5383): 1671–4. doi:10.1126/science.281.5383.1671. ISSN 0036-8075. PMID 9733513. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.