Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9gene.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
^Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R, Karin M (January 1995). "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes Dev8 (24): 2996–3007. doi:10.1101/gad.8.24.2996. PMID8001819.
^Maekawa, Momoko; Nishida Eisuke, Tanoue Takuji (October 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". J. Biol. Chem. (United States) 277 (40): 37783–7. doi:10.1074/jbc.M204506200. ISSN0021-9258. PMID12151396.Cite uses deprecated parameters (help)
^Saleem, A; Datta R, Yuan Z M, Kharbanda S, Kufe D (December 1995). "Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents". Cell Growth Differ. (UNITED STATES) 6 (12): 1651–8. ISSN1044-9523. PMID9019171.Cite uses deprecated parameters (help)
^Kharbanda, S; Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum R, Woodgett J, Avruch J, Kyriakis J (August 1995). "Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase". J. Biol. Chem. (UNITED STATES) 270 (32): 18871–4. doi:10.1074/jbc.270.32.18871. ISSN0021-9258. PMID7642542.Cite uses deprecated parameters (help)
Freedman BD, Liu QH, Del Corno M, Collman RG (2004). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res.27 (2–3): 261–76. doi:10.1385/IR:27:2-3:261. PMID12857973.
Lee C, Liu QH, Tomkowicz B et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.74 (5): 676–82. doi:10.1189/jlb.0503206. PMID12960231.
Denys H, Desmet R, Stragier M et al. (1978). "Cystitis emphysematosa". Acta urologica Belgica45 (4): 327–31. PMID602896.
Chu Y, Solski PA, Khosravi-Far R et al. (1996). "The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation". J. Biol. Chem.271 (11): 6497–501. doi:10.1074/jbc.271.11.6497. PMID8626452.
Bocco JL, Bahr A, Goetz J et al. (1996). "In vivo association of ATFa with JNK/SAP kinase activities". Oncogene12 (9): 1971–80. PMID8649858.
Jabado N, Pallier A, Jauliac S et al. (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol.27 (2): 397–404. doi:10.1002/eji.1830270209. PMID9045910.
Lannuzel A, Barnier JV, Hery C et al. (1998). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol.42 (6): 847–56. doi:10.1002/ana.410420605. PMID9403476.
Fuchs SY, Xie B, Adler V et al. (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem.272 (51): 32163–8. doi:10.1074/jbc.272.51.32163. PMID9405416.