In an era long before satellite distribution of television signals, Mizlou utilized the AT&T system capable of distribution of signals to television stations on a nationwide basis in that era, via a nationwide system of land lines and microwave facilities. Mizlou produced the first "live" coast to coast satellite feed, a New York Cosmos soccer game from San Jose, CA to WOR-TV in New York in the late '70s.
In mid-1965, radio businessman Vincent C. Piano proposed the Unisphere Broadcasting System. The service would have operated 2.5 hours each night. However, Piano had difficulty signing affiliates; a year later, no launch date had been set, and the network still lacked a "respectable number of affiliates in major markets."
Mizlou began syndicating college football bowls in 1962.
Maryland sold Mizlou rights to two of its Atlantic Coast Conference men's basketball games along with the women's basketball Maryland versus Immaculata game on January 26, 1975. This was the first national broadcast of a women’s college basketball game with 100 stations signing on to the telecast.
In August 1989, Mizlou Communications announced the November launch of Sports News Network, a 24 hour sports news and interview basic channel. Mizlou in February 1990 made a private placement of securities to keep SNN going. Mizlou made another attempt before July 1990 and attempted a third placement of $15–$20 million in July 1990 for the network. SNN goes dark on December 17, 1990 as parent Mizlou Communications filed for bankruptcy. Mizlou was in talks with Landmark Communications and Telecable Corporation as a potential buyer of the channel and other assets. In January 1991, Landmark dropped plans for a sport news channel and its discussions with Mizlou for the purchases of Sports News Network due to Tele-Communications Inc.'s planned launch of Prime Sports News, a all sports news cable channel.