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Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms of molecular structure, structural organization, and dynamic behaviour at various levels of complexity (from single molecules to supramolecular structures, viruses and small living systems). The technical challenges are formidable, and the discipline has required development of specialized equipment and procedures capable of imaging and manipulating minute living structures, as well as novel experimental approaches.
Spectroscopy in Molecular Biophysics
Spectroscopic techniques like FT-NMR, spin label electron spin resonance, laser Raman, FT-infrared, circular dichroism, etc have been widely used to understand structural dynamics of important bio-molecules and inter-molecular interactions.
- Gopalasamudram Narayana Iyer Ramachandran, one of the founders of molecular biophysics. Famous for the creation of the Ramachandran plot.
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